Using cutting-edge genetic tools, and NCMIR technologies for 3D electron microscopy, and artificial intelligence, Scripps Research scientists have uncovered key structural hallmarks of long-term memory, called an engram. Their study, published in Science on March 20, 2025, paves the way for future advances in treating memory loss and other cognitive impairments associated with aging and neurodegenerative diseases.

This study investigates the phenomenon of retrolaminar demyelination in structurally intact axons within the context of experimental glaucoma in nonhuman primates, providing new insights into the pathological processes underlying this condition.

Researchers examine the role of astrocytes in the early stages of myelination in the auditory brainstem, revealing that astrocyte ensheathment of axons is a precursor to the rapid expression of myelin genes and subsequent myelination by oligodendrocytes.

Investigators introduce innovative rabies viral tools designed to enhance the mapping of neural circuits across multiple scales, offering significant advancements in neuroscience research.

Researchers explore the intricate 3D ultrastructure of rod photoreceptor synapses under normal conditions and the degenerative changes occurring post-retinal detachment, utilizing advanced electron microscopy techniques.